PHYSICAL PHARMACEUTICS I
Distribution law
PHYSICAL PHARMACEUTICS I
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Solubility of drugs
Solubility of drugs: Solubility expressions
Reading
mechanisms of solute solvent interactions, ideal solubility parameters
Reading
solvation & association, quantitative approach to the factors influencing solubility of drugs
Reading
diffusion principles in biological systems
Reading
Solubility of gas in liquids
Reading
solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law
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real solutions. Partially miscible liquids
Reading
Critical solution temperature and applications.
Reading
Distribution law
Reading
Distribution law, its limitations and applications
Reading
States of Matter and properties of matter
State of matter introduction
Reading
changes in the state of matter, latent heats
Reading
vapour pressure, sublimation critical point, eutectic mixtures, gases
Reading
aerosols – inhalers, relative humidity
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liquid complexes, liquid crystals, glassy states
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solid- crystalline, amorphous & polymorphism.
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Refractive index, optical rotation
Reading
dielectric constant
Reading
dipole moment, dissociation constant
Reading
determinations and applications
Reading
Surface and interfacial phenomenon:
Surface and interfacial phenomenon: Liquid interface
Reading
surface & interfacial tensions
Reading
surface free energy, measurement of surface & interfacial tensions
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spreading coefficient
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adsorption at liquid interfaces
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surface active agents, HLB Scale
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adsorption at solid interface
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solubilisation, detergency
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Complexation and protein binding
Complexation and protein binding: Introduction
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Classification of Complexation, Applications
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methods of analysis
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protein binding,
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Complexation and drug action
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crystalline structures of complexes
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thermodynamic treatment
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thermodynamic treatment of stability constants
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pH, buffers and Isotonic solutions
Applications
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pH, buffers and Isotonic solutions: Sorensen’s pH scale
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pH determination electrometric and calorimetric
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applications of buffers
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buffer capacity
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buffer equation
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buffers in pharmaceutical and biological systems
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buffered isotonic solutions
Reading
Isotonic solutions
Reading
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Exercise Files
C9 DISTRIBUTION LAW (docx)
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