PHYSICAL PHARMACEUTICS I
Complexation and drug action
PHYSICAL PHARMACEUTICS I
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Solubility of drugs
Solubility of drugs: Solubility expressions
Reading
mechanisms of solute solvent interactions, ideal solubility parameters
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solvation & association, quantitative approach to the factors influencing solubility of drugs
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diffusion principles in biological systems
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Solubility of gas in liquids
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solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law
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real solutions. Partially miscible liquids
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Critical solution temperature and applications.
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Distribution law
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Distribution law, its limitations and applications
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States of Matter and properties of matter
State of matter introduction
Reading
changes in the state of matter, latent heats
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vapour pressure, sublimation critical point, eutectic mixtures, gases
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aerosols – inhalers, relative humidity
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liquid complexes, liquid crystals, glassy states
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solid- crystalline, amorphous & polymorphism.
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Refractive index, optical rotation
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dielectric constant
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dipole moment, dissociation constant
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determinations and applications
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Surface and interfacial phenomenon:
Surface and interfacial phenomenon: Liquid interface
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surface & interfacial tensions
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surface free energy, measurement of surface & interfacial tensions
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spreading coefficient
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adsorption at liquid interfaces
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surface active agents, HLB Scale
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adsorption at solid interface
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solubilisation, detergency
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Complexation and protein binding
Complexation and protein binding: Introduction
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Classification of Complexation, Applications
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methods of analysis
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protein binding,
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Complexation and drug action
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crystalline structures of complexes
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thermodynamic treatment
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thermodynamic treatment of stability constants
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pH, buffers and Isotonic solutions
Applications
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pH, buffers and Isotonic solutions: Sorensen’s pH scale
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pH determination electrometric and calorimetric
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applications of buffers
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buffer capacity
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buffer equation
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buffers in pharmaceutical and biological systems
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buffered isotonic solutions
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Isotonic solutions
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Exercise Files
C33 COMPLEXATION AND DRUG ACTION (docx)
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