PHYSICAL PHARMACEUTICS I
Applications
PHYSICAL PHARMACEUTICS I
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Solubility of drugs
Solubility of drugs: Solubility expressions
Reading
mechanisms of solute solvent interactions, ideal solubility parameters
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solvation & association, quantitative approach to the factors influencing solubility of drugs
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diffusion principles in biological systems
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Solubility of gas in liquids
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solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law
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real solutions. Partially miscible liquids
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Critical solution temperature and applications.
Reading
Distribution law
Reading
Distribution law, its limitations and applications
Reading
States of Matter and properties of matter
State of matter introduction
Reading
changes in the state of matter, latent heats
Reading
vapour pressure, sublimation critical point, eutectic mixtures, gases
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aerosols – inhalers, relative humidity
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liquid complexes, liquid crystals, glassy states
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solid- crystalline, amorphous & polymorphism.
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Refractive index, optical rotation
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dielectric constant
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dipole moment, dissociation constant
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determinations and applications
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Surface and interfacial phenomenon:
Surface and interfacial phenomenon: Liquid interface
Reading
surface & interfacial tensions
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surface free energy, measurement of surface & interfacial tensions
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spreading coefficient
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adsorption at liquid interfaces
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surface active agents, HLB Scale
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adsorption at solid interface
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solubilisation, detergency
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Complexation and protein binding
Complexation and protein binding: Introduction
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Classification of Complexation, Applications
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methods of analysis
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protein binding,
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Complexation and drug action
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crystalline structures of complexes
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thermodynamic treatment
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thermodynamic treatment of stability constants
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pH, buffers and Isotonic solutions
Applications
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pH, buffers and Isotonic solutions: Sorensen’s pH scale
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pH determination electrometric and calorimetric
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applications of buffers
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buffer capacity
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buffer equation
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buffers in pharmaceutical and biological systems
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buffered isotonic solutions
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Isotonic solutions
Reading
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Exercise Files
C37 APPLICATIONS OF BUFFERS (docx)
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