BIOCHEMISTRY BP 203T
Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
BIOCHEMISTRY BP 203T
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UNIT 1
Introduction of Biomolecules
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Relation ship between Endergonic and exergonic reaction
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Biological role of biomolecules
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Enthalpy ,Entropy ,Free Energy
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Class test
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UNIT 2
HMP shunt and its significance
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Glycolysis pathway ,Energetics ,significance
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citric acid cycle,energetics,significance
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Glycogen metabolism pathway and glycogen storage diseases
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Gluconeogenesis and its significance
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Hormonal regulation of blood glucose level and Diabetes mellitus
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Biological oxidation
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Electron transport chain and its mechanism , Inhibitors of ETC and oxidative phosphorylation/Uncouplers
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oxidative phosphorylation and its mechnism, Substrate level phosphorylation
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Class test
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UNIT 3
Lipid metabolism ,beta oxidation of fatty acid (palmitic acid)
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Formation and utilization of ketone bodies; ketoacidosis
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De novo synthesis of fatty acids (Palmitic acid)
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Biological significance of cholesterol and conversion of cholesterol into bile acids , conversion of cholesterol into steroid hormone and vitamin D
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Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
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General reactions of amino acid metabolism: Transamination, deamination & decarboxylation
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urea cycle and its disorders
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Catabolism of phenylalanine and tyrosine
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metabolic disorders (Phenylketonuria, Albinism, alkheptonuria, tyrosinemia)
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Synthesis and significance of 5-HT, melatonin, dopamine, noradrenaline, adrenaline, Catabolism of heme; hyperbilirubinemia and jaundice
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Class test
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UNIT 4
Biosynthesis of purine
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Bio synthesis of pyrimidine nucleotides
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Catabolism of purine nucleotides
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Structure of DNA and its functions
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Hyperuricemia and Gout disease
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Organization of mammalian genome
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Structure of RNA and their functions
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DNA replication (semi conservative model)
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Transcription or RNA synthesis , Translation or Protein synthesis and inhibitors
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Genetic code
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Class test
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UNIT 5
ENZYMES
Introduction, properties Of Enzymes
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IUB classification of enzymes and Nomenclature
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Enzyme kinetics (Michaelis plot, Line Weaver Burke plot)
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Enzyme inhibitors with examples
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Regulation of enzymes
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enzyme induction and repression, allosteric enzymes regulation
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Therapeutic and diagnostic applications of enzymes and isoenzymes
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Coenzymes –Structure , Co-enzymes biochemical functions
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Class test
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