PHARMACOLOGY-I 45Hrs | Raghu College Of Pharmacy

Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology
Nature and source of drugs
Essential drugs concept
Routes of drug administration
Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.
Membrane Transport
Absorption, Distribution, metabolism and excretion of drugs
Enzyme induction, enzyme inhibition, kinetics of elimination

Pharmacodynamics- Principles and mechanisms of drug action
Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms
G-protein–coupled receptors
Ion channel receptor
transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors
Dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action.
Adverse drug reactions
Drug interactions (pharmacokinetic and pharmacodynamic)
Drugdiscoveryand clinical evaluation of new drugs-Drug discovery phase, preclinical evaluation phase
clinical trial phase, phases of clinical trials
Pharmacovigilance.

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