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BP402T. MEDICINAL CHEMISTRY – I (Theory)

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About Course

course plan sec B prsec A work loadcourse plan sec B thcourse plan sec Acourse plan sec A prBP402T. MEDICINAL CHEMISTRY – I (Theory)
45 Hours
Scope: This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity
relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class.
Objectives: Upon completion of the course the student shall be able to
1. understand the chemistry of drugs with respect to their pharmacological activity
2. understand the drug metabolic pathways, adverse effect and therapeutic value of drugs
3. know the Structural Activity Relationship (SAR) of different class of drugs
4. write the chemical synthesis of some drugs
Course Content:
Study of the development of the following classes of drugs, Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*)

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Course Content

UNIT 1: Introduction, History and development of medicinal chemistry, Physicochemical properties, & Drug metabolism

  • Introduction, History and development of medicinal chemistry
    00:00
  • Solubility and Partition Coefficient
    00:00
  • Hydrogen Bonding
    00:00
  • Ionization and Protein Binding
    00:00
  • Chelation
    00:00
  • Bioisosterism
    00:00
  • Optical and Geometric Isomerism
    00:00
  • Drug Metabolism, Phase 1 reactions
    00:00
  • Drug Metabolism, Phase 2 reactions
    00:00
  • Factors effecting Drug Metabolism
    00:00

UNIT 2: Drugs acting on Autonomic Nervous System

UNIT 3: Cholinergic neurotransmitters:

UNIT 4: Drugs acting on Central Nervous System

UNIT 5: Drugs acting on Central Nervous System

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