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BP601T. MEDICINAL CHEMISTRY – III

Categories: 6th Semester
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About Course

Scope: This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasis on modern techniques of
rational drug design like quantitative structure activity relationship (QSAR), Prodrug
concept, combinatorial chemistry and Computer aided drug design (CADD). The subject
also emphasizes on the chemistry, mechanism of action, metabolism, adverse effects,
Structure Activity Relationships (SAR), therapeutic uses and synthesis of important
drugs.
Objectives: Upon completion of the course student shall be able to
1. Understand the importance of drug design and different techniques of drug
design.
2. Understand the chemistry of drugs with respect to their biological activity. 3. Know the metabolism, adverse effects and therapeutic value of drugs.
4. Know the importance of SAR of drugs.

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Course Content

UNIT – I Antibiotics
1.1 Antibiotics 1.2 β-Lactam antibiotics 1.3 Aminoglycosides 1.4 Tetracyclines

UNIT – II Antibiotics
2.1 Antibiotics 2.2 Macrolide 2.3 Miscellaneous 2.4 Prodrugs 2.5 Antimalarials 2.6 Quinolines 2.7 Biguanides and dihydro triazines 2.8 Miscellaneous

UNIT – III Anti-tubercular Agents
3.1 Synthetic anti tubercular agents 3.2 Anti tubercular antibiotics 3.3 Urinary tract anti-infective agents Quinolones 3.4 Miscellaneous 3.5 Antiviral agents

UNIT – IV Antifungal agents:
4.1 Antifungal antibiotics 4.2 Synthetic Antifungal agents 4.3 Anti-protozoal Agents 4.4 Anthelmintics 4.5 Sulphonamides and Sulfones 4.6 Folate reductase inhibitors 4.7 Sulfones

UNIT – V Introduction to Drug Design
5.1 Introduction to Drug Design 5.2 Combinatorial Chemistry

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