BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III (Theory)

Categories: 4th Semester

About Course

Scope: This subject imparts knowledge on stereo-chemical aspects of organic compounds

and organic reactions, important named reactions, chemistry of important hetero cyclic

compounds. It also emphasizes on medicinal and other uses of organic compounds.

Objectives: At the end of the course, the student shall be able to

1. understand the methods of preparation and properties of organic compounds

2. explain the stereo chemical aspects of organic compounds and stereo chemical

reactions

3. know the medicinal uses and other applications of organic compounds

Course Content:

Note: To emphasize on definition, types, mechanisms, examples, uses/applications

Course Content

UNIT I – Stereo isomerism
Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers Reactions of chiral molecules Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute

UNIT-II Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) Methods of determination of configuration of geometrical isomers. Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. Stereospecific and stereoselective reactions

UNIT III – Heterocyclic compounds:
Nomenclature and classification Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

UNIT-IV Synthesis, reactions and medicinal uses of following compounds/derivatives
Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

UNIT-V Reactions of synthetic importance
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction. Oppenauer-oxidation and Dakin reaction. Beckmanns rearrangement and Schmidt rearrangement. Claisen-Schmidt condensation

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