About Course
Scope: The course deals with the various physica and physicochemical properties, and
principles involved in dosage forms/formulations. Theory and practical
components of the subject help the student to get a better insight into various
areas of formulation research and development, and stability studies of
pharmaceutical dosage forms.
Objectives: Upon the completion of the course student shall be able to
1. Understand various physicochemical properties of drug molecules in the
designing the dosage forms
2. Know the principles of chemical kinetics & to use them for stability testing nad
determination of expiry date of formulations
3. Demonstrate use of physicochemical properties in the formulation
development and evaluation of dosage form
Course Content
unit I SOLUBILITY OF DRUGS
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mechanisms of solute solvent interactions,
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ideal solubility parameters, solvation & association
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quantitative approach to the factors influencing solubility of drugs,
00:00 -
diffusion principles in biological systems.
00:00 -
Solubility of gas in liquids
00:00 -
, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions
00:00 -
s. Partially miscible liquids, Critical solution temperature and applications
00:00 -
Distribution law, its limitations and application
00:00 -
METHODS TO ENHANCE SOLUBILITY
00:00
unit II States of Matter and properties of matter:
unit III Surface and interfacial phenomenon:
unit IV Complexation and protein binding
unit V pH, buffers and Isotonic solutions:
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