BP302T. PHYSICAL PHARMACEUTICS-I (Theory) | Raghu College Of Pharmacy

About Course

Scope: The course deals with the various physica and physicochemical properties, and
principles involved in dosage forms/formulations. Theory and practical
components of the subject help the student to get a better insight into various
areas of formulation research and development, and stability studies of
pharmaceutical dosage forms.
Objectives: Upon the completion of the course student shall be able to
1. Understand various physicochemical properties of drug molecules in the
designing the dosage forms
2. Know the principles of chemical kinetics & to use them for stability testing nad
determination of expiry date of formulations
3. Demonstrate use of physicochemical properties in the formulation
development and evaluation of dosage forms

Course Content

UNIT I – Solubility of drugs
Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partiallymiscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications

UNIT II – States of Matter and properties of matter
State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solidcrystalline, amorphous & polymorphism.

Physicochemical properties of drug molecules
Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications

UNIT III – Surface and interfacial phenomenon
Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.

UNIT IV – Complexation and protein binding
Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants

UNIT-V pH, buffers and Isotonic solutions
Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.

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