BP 704T: NOVEL DRUG DELIVERY SYSTEMS (Theory)

About Course

Scope: This subject is designed to impart basic knowledge on the area of novel drug
delivery systems.
Objectives: Upon completion of the course student shall be able
1. To understand various approaches for development of novel drug delivery systems.
2. To understand the criteria for selection of drugs and polymers for the development of
Novel drug delivery systems, their formulation and evaluation

Recommended Books: (Latest Editions)
1. Y W. Chien, Novel Drug Delivery Systems, 2
nd edition, revised and expanded,
Marcel Dekker, Inc., New York, 1992.
2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992.
3. Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley
Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim
4. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors,
New Delhi, First edition 1997 (reprint in 2001).
5. S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances,
Vallabh Prakashan, New Delhi, First edition 2002.

Course Content

Unit-I Controlled drug delivery systems:
: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations

Polymers
Introduction, classification, properties, advantages and application of poly ymers in formulation of controlled release drug delivery systems.

Unit-II Microencapsulation:
Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications

Mucosal Drug Delivery system:
Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems
Introduction, advantages and disadvantages, concept of implantsand osmotic pump

Unit-III Transdermal Drug Delivery Systems
Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches

Gastroretentive drug delivery systems
Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications

Nasopulmonary drug delivery system
Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

Unit-IV Targeted drug Delivery
Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

Unit-V Ocular Drug Delivery Systems
Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts

Intrauterine Drug Delivery Systems
Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications

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Course Content

Polymers Introduction, classification, properties, advantages and application of poly ymers in formulation of controlled release drug delivery systems.

Unit-II Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications

Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems

Implantable Drug Delivery Systems Introduction, advantages and disadvantages, concept of implantsand osmotic pump

Unit-III Transdermal Drug Delivery Systems Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches

Gastroretentive drug delivery systems Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications

Nasopulmonary drug delivery system Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers

Unit-IV Targeted drug Delivery Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications

Unit-V Ocular Drug Delivery Systems Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts

Intrauterine Drug Delivery Systems Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications