Course Content
unit I SOLUBILITY OF DRUGS
Solubility expressions, mechanisms of solute solvent interactions
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Solubility expressions
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mechanisms of solute solvent interactions,
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ideal solubility parameters, solvation & association
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quantitative approach to the factors influencing solubility of drugs,
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diffusion principles in biological systems.
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Solubility of gas in liquids
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, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions
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s. Partially miscible liquids, Critical solution temperature and applications
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Distribution law, its limitations and application
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METHODS TO ENHANCE SOLUBILITY
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unit II States of Matter and properties of matter:
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State of matter, changes in the state of matter
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Inter molecular bonding forces
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Gaseous state,gas laws Ideal gas equation, Vanderwall equation for real gases
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Kinetic molecular theory Introduction Liquid state,liquefaction of gases
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Aerosols, latent heats, vapour pressure, Heat of Vaporiszation,solid state Polymorphism , Solvates.Amorphous solids
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Refractive index
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optical rotation,
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dielectric constant,
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dipole moment
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dissociation constant
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unit III Surface and interfacial phenomenon:
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Liquid interface, surface & interfacial tensions,
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surface free energy, measurement of surface tension
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measurement of interfacial tension
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spreading coefficient,applications adsorption at liquid interfaces,
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surface active agents, HLB Scale, Solubilisation, detergency
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adsorption at solid interface
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adsorption at solid interface
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Electrical properties of interfaces
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unit IV Complexation and protein binding
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Complexation-introduction,applications
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Inorganic complexes,classification,organic complexes
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Inclusion complexes,applications
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Methods of analysis
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Methods of analysis
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Protein binding
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Thermodynamic treatment of stability constants.
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Crystalline structures of complexes Complexation and drug action
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complexation
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unit V pH, buffers and Isotonic solutions:
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Sorensen’s pH scale, pH determination pH determination
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applications of buffers,
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buffer equation buffer capacity
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buffers in pharmaceutical and biological systems
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buffered isotonic solutions
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Methods to adjust isotonicity
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Influence of buffer capacity and pH on tissue irritation
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BP302T. PHYSICAL PHARMACEUTICS-I (Theory)
Exercise Files
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